Key result
No commercially available cardiac troponin assay was able to achieve the recommended 10% coefficient of variation at the 99th percentile reference limit defined by the manufacturer.
Why the study?
Do commercially available cardiac troponin assays achieve a 10% coefficient of variation at the 99th percentile reference limit?
Do commercially available cardiac troponin assays achieve a 10% coefficient of variation at the 99th percentile reference limit?
At the time of the study, no commercially available cardiac troponin assay could achieve the recommended 10% imprecision (CV) at the 99th percentile reference limit for diagnosing myocardial infarction.
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Current assays undermine reliable MI diagnosis at manufacturer 99th percentiles; challenges ESC/ACC imprecision standards and leaves open revised criteria.
Panteghini et al. (2004) studied Myocardial Infarction. Commercially available cardiac troponin assays was evaluated on Lowest concentration associated with a 10% CV. No commercially available cardiac troponin assay was able to achieve the recommended 10% coefficient of variation at the 99th percentile reference limit defined by the manufacturer.
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