Key result
No commercially available cardiac troponin assay was able to achieve the recommended 10% coefficient of variation at the 99th percentile reference limit defined by the manufacturer.
Why the study?
Do commercially available cardiac troponin assays achieve a 10% coefficient of variation at the 99th percentile reference limit?
Population
Eight human serum pools targeting different concentrations of cardiac troponin around the myocardial…
Authors
Loading...
Current assays undermine reliable MI diagnosis at manufacturer 99th percentiles; challenges ESC/ACC imprecision standards and leaves open revised criteria.
Do commercially available cardiac troponin assays achieve a 10% coefficient of variation at the 99th percentile reference limit?
At the time of the study, no commercially available cardiac troponin assay could achieve the recommended 10% imprecision (CV) at the 99th percentile reference limit for diagnosing myocardial infarction.
Panteghini et al. (2004) studied Myocardial Infarction. Commercially available cardiac troponin assays was evaluated on Lowest concentration associated with a 10% CV. No commercially available cardiac troponin assay was able to achieve the recommended 10% coefficient of variation at the 99th percentile reference limit defined by the manufacturer.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: