Key result
An immunohistochemical panel of CDK4, MDM2, and p16 detected well-differentiated and dedifferentiated liposarcomas with 71% sensitivity and 98% specificity, with p16 being the most accurate marker.
Why the study?
Does an immunohistochemical panel of p16, CDK4, and MDM2 accurately distinguish well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors?
Population
216 adipocytic neoplasms
Design
Cross-sectional
Authors
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May aid liposarcoma distinction in adipocytic tumors; leaves open prospective validation before routine use.
Observational (n=216)
Does an immunohistochemical panel of p16, CDK4, and MDM2 accurately distinguish well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors?
An immunohistochemical panel of CDK4, MDM2, and p16 is highly specific for distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors, with p16 being the most sensitive and specific individual marker.
Thway et al. (2012) conducted an observational in Adipocytic tumors (n=216). Immunohistochemistry for CDK4, MDM2, and p16 was evaluated on Sensitivity and specificity for detecting well-differentiated and dedifferentiated liposarcomas. An immunohistochemical panel of CDK4, MDM2, and p16 detected well-differentiated and dedifferentiated liposarcomas with 71% sensitivity and 98% specificity, with p16 being the most accurate marker.
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