Key result
Immunohistochemistry for MDM2 and CDK4 identifies WDLPS and DDLPS, achieving up to 100% and 98.8% specificity respectively when strong immunoreactivity is present in >30% of neoplastic cells.
Why the study?
Can immunohistochemistry for MDM2 and CDK4 accurately diagnose well differentiated and dedifferentiated liposarcomas among soft tissue tumours?
Population
129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours, including well differentiated…
Comparison
Immunohistochemistry (IHC) for MDM2 and CDK4 vs Comparison between tumour types
Design
Cross-sectional
Authors
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MDM2/CDK4 IHC may aid specific WDLPS/DDLPS diagnosis; leaves open prospective validation before routine use.
Cross-Sectional (n=129)
Can immunohistochemistry for MDM2 and CDK4 accurately diagnose well differentiated and dedifferentiated liposarcomas among soft tissue tumours?
Detection of MDM2 and CDK4 protein overexpression by immunohistochemistry, particularly with a strong and diffuse pattern in >30% of cells, is a highly specific method for diagnosing well differentiated and dedifferentiated liposarcomas.
Aleixo et al. (2009) conducted a cross-sectional in Well differentiated and dedifferentiated liposarcomas (n=129). Immunohistochemistry for MDM2 and CDK4 vs. Standard histopathological diagnosis was evaluated on Diagnostic sensitivity and specificity of MDM2 and CDK4 immunostaining. Immunohistochemistry for MDM2 and CDK4 identifies WDLPS and DDLPS, achieving up to 100% and 98.8% specificity respectively when strong immunoreactivity is present in >30% of neoplastic cells.
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