Key result
MDM2 immunohistochemistry correlates with FISH yielding 100% specificity for identifying dedifferentiated liposarcoma.
Why the study?
Does MDM2 FISH and IHC help distinguish dedifferentiated liposarcoma from other high-grade sarcomas?
Population
85 cases of nonlipogenic high-grade sarcomas diagnosed between 2008 and 2011
Design
Cohort
Authors
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MDM2 IHC may substitute for FISH in dedifferentiated liposarcoma diagnosis; leaves open need for prospective validation before routine use.
Observational (n=85)
Does MDM2 FISH and IHC help distinguish dedifferentiated liposarcoma from other high-grade sarcomas?
Effect estimate: Sensitivity 92.7%, Specificity 100%
p-value: p=<0.001
MDM2 amplification and expression testing via FISH and IHC is highly sensitive and specific for distinguishing dedifferentiated liposarcoma from other high-grade sarcomas.
Song et al. (2016) conducted an observational in High-grade spindle and pleomorphic sarcomas (n=85). MDM2 fluorescence in situ hybridization and immunohistochemistry was evaluated on Correlation between MDM2 immunohistochemistry and fluorescence in situ hybridization (Sensitivity 92.7%, Specificity 100%, p=<0.001). MDM2 immunohistochemistry and fluorescence in situ hybridization showed excellent correlation (P<0.001, sensitivity 92.7%, specificity 100%) for distinguishing dedifferentiated liposarcoma.
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