Global extracellular volume was an independent predictor of arrhythmic burden in patients with dilated cardiomyopathy, with each 1% increase in ECV increasing the risk of arrhythmic burden by 12% (HR 1.12).
Observational (n=99)
No
Does CMR-derived extracellular volume predict arrhythmic burden in patients with dilated cardiomyopathy?
CMR-derived extracellular volume, a marker of interstitial fibrosis, is an independent predictor of arrhythmic burden in patients with dilated cardiomyopathy, whereas replacement fibrosis (LGE) is not.
Estimación del efecto: HR 1.12 (95% CI 1.0-1.25)
valor p: p=<0.02
The current stratification of arrhythmic risk in dilated cardiomyopathy (DCM) is sub-optimal. Cardiac fibrosis is involved in the pathology of arrhythmias; however, the relationship between cardiovascular magnetic resonance (CMR) derived extracellular volume (ECV) and arrhythmic burden (AB) in DCM is unknown. This study sought to evaluate the presence and extent of replacement and interstitial fibrosis in DCM and to compare the degree of fibrosis between DCM patients with and without AB. This is a prospective, single-center, observational study. Between May 2019 and September 2020, 102 DCM patients underwent CMR T1 mapping. 99 DCM patients (88 male, mean age 45.2 ± 11.8 years, mean EF 29.7 ± 10%) composed study population. AB was defined as the presence of VT or a high burden of PVCs. There were 41 (41.4%) patients with AB and 58 (58.6%) without AB. Replacement fibrosis was assessed with late gadolinium enhancement (LGE), whereas interstitial fibrosis with ECV. Overall, LGE was identified in 41% of patients. There was a similar distribution of LGE (without AB 50% vs. with AB 53.7%; p = 0.8) and LGE extent (without AB 4.36 ± 5.77% vs. with AB 4.68 ± 3.98%; p = 0.27) in both groups. ECV at nearly all myocardial segments and a global ECV were higher in patients with AB (global ECV: 27.9 ± 4.9 vs. 30.3 ± 4.2; p < 0.02). Only indexed left ventricular end-diastolic diameter (HR 1.1, 95%CI 1.0-1.2; p < 0.02) and global ECV (HR 1.12, 95%CI 1.0-1.25; p < 0.02) were independently associated with AB. The global ECV cut-off value of 31.05% differentiated both groups (AUC 0.713; 95%CI 0.598-0.827; p < 0.001). Neither qualitative nor quantitative LGE-based assessment of replacement fibrosis allowed for the stratification of DCM patients into low or high AB. Interstitial fibrosis, expressed as ECV, was an independent predictor of AB in DCM. Incorporation of CMR parametric indices into decision-making processes may improve arrhythmic risk stratification in DCM.
Rubiś et al. (Tue,) conducted a observational in Dilated cardiomyopathy (n=99). Extracellular volume (ECV) assessment was evaluated on Arrhythmic burden (presence of VT or high burden of PVCs) (HR 1.12, 95% CI 1.0-1.25, p=<0.02). Global extracellular volume was an independent predictor of arrhythmic burden in patients with dilated cardiomyopathy, with each 1% increase in ECV increasing the risk of arrhythmic burden by 12% (HR 1.12).