Key result
Intrapericardial delivery of paclitaxel significantly reduced neointimal area (0.47 mm2 [low dose] and 0.51 mm2 [high dose] vs 0.79 mm2; P<0.001) after porcine coronary overstretch.
Why the study?
Does intrapericardial paclitaxel delivery inhibit neointimal proliferation after balloon overstretch in a porcine model?
Does intrapericardial paclitaxel delivery inhibit neointimal proliferation after balloon overstretch in a porcine model?
Absolute Event Rate: 0.47% vs 0.79%
p-value: p=<0.001
Intrapericardial delivery of paclitaxel significantly reduces neointimal proliferation and promotes positive vascular remodeling in a porcine model of coronary overstretch injury.
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Hypothesis-generating for intrapericardial paclitaxel to limit restenosis; human studies required before clinical translation.
Hou et al. (2000) studied Coronary overstretch injury (n=18). Intrapericardial paclitaxel vs. Control micelles (50 mg) was evaluated on Neointimal area (mm2) (p=<0.001). Intrapericardial delivery of paclitaxel significantly reduced neointimal area (0.47 mm2 [low dose] and 0.51 mm2 [high dose] vs 0.79 mm2; P<0.001) after porcine coronary overstretch.
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