Key result
Catheter-based transmyocardial delivery of adenoviral vectors to the pericardial space in dogs achieved up to 100% gene expression in pericardial lining endothelium without clinical sequelae.
Why the study?
Does catheter-based transmyocardial delivery of adenoviral vectors achieve efficient gene expression in the pericardium of mongrel dogs?
Does catheter-based transmyocardial delivery of adenoviral vectors achieve efficient gene expression in the pericardium of mongrel dogs?
Catheter-based transmyocardial delivery of adenoviral vectors to the pericardial space is feasible and results in highly efficient, localized gene expression in a canine model.
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Not ready for clinical translation; leaves open whether pericardial gene delivery advances to human cardiac applications.
March et al. (1999) studied diseases of the heart and coronary vessels. catheter-based pericardial gene transfer mediated by adenoviral vectors was evaluated on reporter gene expression in pericardium, epicardium, and multiple other tissues. Catheter-based transmyocardial delivery of adenoviral vectors to the pericardial space in dogs achieved up to 100% gene expression in pericardial lining endothelium without clinical sequelae.
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