September 16, 1997Circulation
Effect of Intravascular Irradiation on Cell Proliferation, Apoptosis, and Vascular Remodeling After Balloon Overstretch Injury of Porcine Coronary Arteries
Key result
Intravascular irradiation significantly reduced early cell proliferation and improved late vascular remodeling by preventing adventitial fibrosis after balloon injury in porcine coronary arteries.
Why the study?
Does intravascular irradiation reduce cell proliferation and improve vascular remodeling after balloon overstretch injury in porcine coronary arteries?
Population
Porcine coronary arteries subjected to balloon overstretch injury
Comparison
Intravascular ionizing radiation using a source… vs Nonirradiated control vessels subjected to…
Design
Preclinical
Follow-up
up to 14 days
Authors
Discussion
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Implication
Intravascular irradiation may limit post-injury fibrosis in pigs; hypothesis-generating and should not yet inform human practice.
Structured PICO
Does intravascular irradiation reduce cell proliferation and improve vascular remodeling after balloon overstretch injury in porcine coronary arteries?
P
Population
Porcine coronary arteries subjected to balloon overstretch injury, evaluated at 3, 7, or 14 days post-injury.
I
Intervention
Intravascular ionizing radiation using a source train of 90Sr/Y or 192Ir seeds designed to deliver 14 or 28 Gy at a depth of 2 mm from the source, administered immediately after balloon injury
C
Comparator
Nonirradiated control vessels subjected to balloon injury
O
Outcome
Cell proliferation, apoptosis (TUNEL), and vascular remodeling (vessel perimeter, alpha-actin-positive myofibroblasts) at 3, 7, or 14 days after injurysurrogate
Intravascular irradiation inhibits early cell proliferation and prevents adventitial fibrosis, promoting favorable vascular remodeling after balloon injury in a porcine model.
Cite This Study
Waksman et al. (1997) studied Balloon overstretch injury of porcine coronary arteries. Ionizing radiation (90Sr/Y or 192Ir seeds) vs. Nonirradiated controls was evaluated on Cell proliferation, apoptosis, and vascular remodeling. Intravascular irradiation significantly reduced early cell proliferation and improved late vascular remodeling by preventing adventitial fibrosis after balloon injury in porcine coronary arteries.