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May 1, 1994Journal of the American College of CardiologyOpen Access

Intracoronary irradiation markedly reduces restenosis after balloon angioplasty in a porcine model

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Why the study?

Does intracoronary irradiation reduce neointimal proliferation and restenosis after balloon angioplasty in a porcine model?

Population

19 juvenile swine (normolipemic swine model of restenosis)

Comparison

Intracoronary irradiation followed by… vs Overdilation balloon angioplasty without…

Design

Preclinical, Histopathologic analysis was performed by a pathologist in…

Follow-up

30 days

Authors

JWJ WiedermannNewYork–Presbyterian HospitalCMCharles C. MarboeCross-Cutting CardiologyHAHoward AmolsMemorial Sloan Kettering Cancer Center

Discussion

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Implication

Does not alter clinical practice; leaves open translation of irradiation to human restenosis prevention.

Structured PICO

Does intracoronary irradiation reduce neointimal proliferation and restenosis after balloon angioplasty in a porcine model?

P
Population
19 juvenile swine (normolipemic swine model of restenosis)
I
Intervention
Intracoronary irradiation (2,000 cGy delivered via iridium-192 ribbon) followed by overdilation balloon angioplasty
C
Comparator
Overdilation balloon angioplasty without previous irradiation
O
Outcome
Neointimal area and percent area stenosis at 30 days, assessed by blinded histopathologic analysis and computer-assisted planimetrysurrogate

Intracoronary irradiation prior to balloon angioplasty significantly reduces neointima formation and restenosis in a porcine model.

Cite This Study

Wiedermann et al. (1994) studied this question.

synapsesocial.com/papers/6a7755e598f24dbf64bd7dfdhttps://doi.org/10.1016/0735-1097(94)90397-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of pathologic and angiographic findings in a porcine preparation of coronary atherosclerosis.1985 · 43 citations
  2. 2Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease.1992 · 1,341 citations
  3. 3Restenosis after balloon angioplasty. A practical proliferative model in porcine coronary arteries.1990 · 410 citations
  4. 4Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model.1985 · 635 citations
  5. 5Restenosis after successful coronary angioplasty in patients with single-vessel disease.1986 · 694 citations