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September 1, 1997Current Opinion in Cardiology

Intracoronary irradiation for the prevention of restenosis

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Why the study?

Does intracoronary irradiation prevent restenosis after coronary angioplasty?

Population

Patients with atherosclerotic coronary artery disease undergoing coronary angioplasty

Design

Review

Authors

JWJudah WeinbergerTouro CollegeASAlan D. SimonRoyal Brompton & Harefield NHS Foundation Trust

Discussion

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Implication

Should not yet change clinical practice; leaves open efficacy and dosing confirmation in randomized trials.

Structured PICO

Does intracoronary irradiation prevent restenosis after coronary angioplasty?

P
Population
Patients with atherosclerotic coronary artery disease undergoing coronary angioplasty
I
Intervention
Intracoronary irradiation
O
Outcome
Restenosis (angiographic and clinical)

Intracoronary irradiation is a promising experimental technique for preventing restenosis after angioplasty, though optimal dosing and delivery methods require further study.

Limitations

  • Unresolved target tissue for radiation
  • Unknown minimal effective dose
  • Unknown maximum tolerable dose
  • Lack of user-friendly radiation delivery systems

Cite This Study

Weinberger et al. (1997) studied this question.

synapsesocial.com/papers/6a82c5efd88fdfcf4fa0cbb9https://doi.org/10.1097/00001573-199709000-00006

Topics

Coronary artery disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracoronary irradiation for the prevention of restenosis1997 · 15 citations
  2. 2Intracoronary radiotherapy for prevention of restenosis after percutaneous coronary interventions2000 · 3 citations
  3. 3Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting2001 · 653 citations
  4. 4Catheter-Based Radiotherapy to Inhibit Restenosis after Coronary Stenting1997 · 944 citations
  5. 5Intracoronary γ-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis2000 · 537 citations