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September 1, 1997Current Opinion in Cardiology

Intracoronary irradiation for the prevention of restenosis

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Why the study?

Does intracoronary irradiation prevent restenosis after coronary angioplasty in patients with atherosclerotic coronary artery disease?

Population

Patients with atherosclerotic coronary artery disease undergoing coronary angioplasty

Design

Review

Authors

JWJudah WeinbergerTouro CollegeASAlan D. SimonRoyal Brompton & Harefield NHS Foundation Trust

Discussion

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Implication

May support further trials of intracoronary irradiation for restenosis; leaves open optimal dosing before clinical adoption.

Structured PICO

Does intracoronary irradiation prevent restenosis after coronary angioplasty in patients with atherosclerotic coronary artery disease?

P
Population
Patients with atherosclerotic coronary artery disease undergoing coronary angioplasty
I
Intervention
Intracoronary irradiation
O
Outcome
Restenosis

Intracoronary irradiation emerges as a potential novel therapy to prevent restenosis post-angioplasty, though significant technical and dosimetric challenges remain.

Limitations

  • Unresolved issues regarding target tissue
  • Unresolved minimal effective dose
  • Unresolved maximum tolerable dose
  • Need for user-friendly radiation delivery systems

Cite This Study

Weinberger et al. (1997) studied this question.

synapsesocial.com/papers/6a82c5efd88fdfcf4fa0cbbahttps://doi.org/10.1097/00001573-199712050-00006
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intracoronary irradiation for the prevention of restenosis1997 · 18 citations
  2. 2Intracoronary radiotherapy for prevention of restenosis after percutaneous coronary interventions2000 · 3 citations
  3. 3Localized Intracoronary Gamma-Radiation Therapy to Inhibit the Recurrence of Restenosis after Stenting2001 · 653 citations
  4. 4Catheter-Based Radiotherapy to Inhibit Restenosis after Coronary Stenting1997 · 944 citations
  5. 5Intracoronary γ-Radiation Therapy After Angioplasty Inhibits Recurrence in Patients With In-Stent Restenosis2000 · 537 citations