Key result
Cardiac MRI in Filamin C-associated cardiomyopathy reveals marked concentric midmyocardial LGE and elevated native T1.
Case Report (n=1)
Cardiac MRI in a patient with Filamin C-associated cardiomyopathy revealed a characteristic concentric midmyocardial late gadolinium enhancement pattern with elevated native T1 mapping.
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MRI phenotype in this single case should not alter practice; leaves open diagnostic utility in FLNC cardiomyopathy pending larger studies.
C ardiac MRI was performed in a previously healthy 21-year-old male patient who presented with palpitations, sustained ventricular tachycardia, and elevated troponin levels.Imaging showed that the left ventricle was nondilated with normal function (ejection fraction, 61%) (Movie).Postcontrast T1-weighted images demonstrated marked concentric ("ringlike") midmyocardial late gadolinium enhancement throughout the left ventricle (Figure , A andB), with a corresponding elevated native T1 mapping value of 1120 msec (a normal value at our institution is <1100 msec) (Figure ,C).These findings suggested fibrosis and scarring in a nonischemic pattern.Subsequent genetic
Weller et al. (2023) conducted a case report in Filamin C-associated Cardiomyopathy (n=1). Cardiac MRI was evaluated on Cardiac MRI findings. Cardiac MRI in a 21-year-old male with Filamin C-associated cardiomyopathy demonstrated marked concentric midmyocardial late gadolinium enhancement and an elevated native T1 mapping value of 1120 msec.
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