Hypoperfused acute heart failure phenotypes (cold+wet and cold+dry) had higher 1-year mortality than the warm+dry phenotype (HR 1.660, CI 1.400-1.968 and HR 1.672, CI 1.189-2.351).
Cohort (n=11,261)
Yes
Does clinical phenotyping based on congestion and perfusion at ED presentation predict outcomes in patients with acute heart failure?
Bedside clinical evaluation of congestion and perfusion in AHF patients at ED arrival provides useful prognostic information, with hypoperfused phenotypes showing significantly higher 1-year mortality.
Effect estimate: HR 1.660 (cold+wet); HR 1.672 (cold+dry) (95% CI 1.400-1.968; 1.189-2.351)
OBJECTIVE: To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). METHODS AND RESULTS: Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm + wet, 1929 (17.1%) cold + wet, 675 (6.0%) warm + dry, and 99 (0.9%) cold + dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm + wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm + dry, the adjusted hazard ratios were significantly increased for cold + wet (1.660; 95% confidence interval 1.400-1.968) and cold + dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. CONCLUSIONS: Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival.
Javaloyes et al. (Sat,) conducted a cohort in Acute heart failure (n=11,261). Clinical phenotypes based on congestion and perfusion vs. Warm + dry phenotype was evaluated on 1-year all-cause mortality (HR 1.660 (cold+wet); HR 1.672 (cold+dry), 95% CI 1.400-1.968; 1.189-2.351). Hypoperfused acute heart failure phenotypes (cold+wet and cold+dry) had higher 1-year mortality than the warm+dry phenotype (HR 1.660, CI 1.400-1.968 and HR 1.672, CI 1.189-2.351).