Key result
Higher uric acid to HDL ratio linked to increased baPWV, particularly in females.
Why the study?
UA and HDL-C levels are closely linked to CVD morbidity, but whether the uric acid to HDL-cholesterol ratio is associated with or affects arterial stiffness remains to be determined.
Is the serum uric acid to high density lipoprotein-cholesterol ratio (UHR) associated with arterial stiffness (baPWV) in a Japanese population?
Cross-Sectional (n=912)
No
Is the serum uric acid to high density lipoprotein-cholesterol ratio (UHR) associated with arterial stiffness (baPWV) in a Japanese population?
The uric acid to HDL-cholesterol ratio is non-linearly associated with arterial stiffness in Japanese adults, particularly in women and those with normal BMI and no fatty liver.
UHR association with stiffness in women is hypothesis-generating; leaves open any role in risk prediction or practice without longitudinal data.
Uric acid (UA) and HDL-cholesterol (HDL-C) level are closely associated to the cardiovascular disease (CVD) morbidity. The UA/HDL-C ratio (UHR), a new parameter combination of serum UA and HDL-C, attracts attention for its association with metabolic and inflammatory conditions. There may exists the association between UHR and arterial stiffness. This study aims to explore the association between the UHR and brachial-ankle PWV (baPWV) and to determine whether or not UHR has effect on arterial stiffness. The present study included a total of 912 Japanese (592 men and 320 women), aged from 24 to 84, received a health medical checkup programme with an automatic waveform analyzer to measure baPWV and various standardized questionnaires in a medical center of Japan. Non-linear regression and threshold effect analysis were conducted to explore the association between UHR and baPWV. It was found that UHR was positively correlated with baPWV after adjusting for multiple confounders. A non-linear relationship (with a inflection point was 14.25) was found between UHR and baPWV. Subgroup analyses showed that the significant association between UHR and baPWV only existed in females group, no fatty liver group and normal BMI groups. This study revealed the nonlinear relationship between UHR and baPWV. A significant correlation between UHR and baPWV existed in females but not in males. Fatty liver status, BMI, and menopausal status may affect the above association.
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Wang et al. (2023) conducted a cross-sectional in General population undergoing health checkup (n=912). Serum uric acid to high density lipoprotein-cholesterol ratio (UHR) was evaluated on Brachial-ankle pulse wave velocity (baPWV). The serum uric acid to HDL-cholesterol ratio (UHR) was positively correlated with brachial-ankle pulse wave velocity in a non-linear manner (inflection point 14.25), particularly in females.
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