Key result
Urinary uric acid excretion was significantly associated with an increased risk of arterial stiffness (OR 1.028; 95% CI 1.016-1.040) in Chinese adults.
Why the study?
Hyperuricemia is associated with cardiovascular risk, possibly mediated by arterial stiffness, but the association of blood and urine uric acid with arterial stiffness needed evaluation in a Chinese cohort.
Is urinary uric acid excretion associated with arterial stiffness in Chinese adults?
Cohort (n=2,296)
Is urinary uric acid excretion associated with arterial stiffness in Chinese adults?
Odds Ratio: 1.028 (95% CI 1.016–1.04)
p-value: p=0.033
Urinary uric acid excretion is significantly associated with arterial stiffness in Chinese adults, suggesting its potential as a noninvasive marker for early detection.
Urinary UA excretion was associated with arterial stiffness; leaves open causal role or therapeutic targeting in adults.
BACKGROUND: Hyperuricemia has long been associated with increased cardiovascular risk, and arterial stiffness is proposed as a mediator. The present study is aimed at examining the associations of uric acid (UA) in blood and urine with arterial stiffness in a Chinese cohort. METHODS: A total of 2296 participants (mean age: 43.0 years) from our previously established cohort of Hanzhong Adolescent Hypertension Study were included. The participants were classified as subjects with or without arterial stiffness, which was defined as brachial-ankle pulse wave velocity (baPWV) ≥ 1400 cm/s and/or carotid intima-media thickness (CIMT) ≥ 0.9 mm. Multivariate regression analyses were used to examine the relationship between serum and urinary UA and the risk of arterial stiffness after adjusting for age, gender, systolic blood pressure, fasting glucose, BMI, heart rate, total cholesterol, and triglycerides. RESULTS: = 0.033) in all subjects. In addition, uUA/Cre was significantly associated with the risk of high baPWV [1.032 (1.019-1.045)] and arterial stiffness [1.028 (1.016-1.040)]. CONCLUSION: Our study showed that urinary UA excretion was significantly associated with the risk of arterial stiffness in Chinese adults. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of arterial stiffness in otherwise healthy subjects.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2020) conducted a cohort in Arterial stiffness (n=2,296). Uric acid in serum and urine (uUA/Cre) was evaluated on Arterial stiffness (baPWV ≥ 1400 cm/s and/or CIMT ≥ 0.9 mm) (OR 1.028, 95% CI 1.016-1.040, p=0.033). Urinary uric acid excretion was significantly associated with an increased risk of arterial stiffness (OR 1.028; 95% CI 1.016-1.040) in Chinese adults.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: