The impact of serum acid, arterial stiffness, and hypertension as a mediating factor: A cohort study

Serum uric acid (SUA) has been associated arterial stiffness. However, previous studies were limited to contradicting cross-sectional studies. This study aimed to examine the longitudinal association between SUA and progression of arterial stiffness and the potential mechanisms. Based on the Kailuan study, arterial stiffness progression was assessed by the annual growth rate of repeatedly measured brachial-ankle pulse wave velocity (baPWV). Generalized linear regression models were used to estimate the association of SUA with baseline arterial stiffness (n=37,659) and arterial stiffness progression (n=16,506), and Cox regressions were used to investigate the risk of incident arterial stiffness (n=13,843). Mediation analysis was used to explore the potential mediators of the associations. Per standard deviation increase in SUA was associated with an 11.89 cm/s increment (95% confidence interval [CI], 8.60-15.17) in baseline baPWV and a 2.67 cm/s/yr increment in the annual growth rate of baPWV. During 5.77-year follow-up, there were 1953 cases of incident arterial stiffness. Participants in the highest quartile of SUA had a 39% higher risk of arterial stiffness (HR, 1.39; 95%CI, 1.21–1.60), as compared with those in the lowest quartile of SUA. Furthermore, the observed associations were more pronounced in women than that in men (Pint<0.05). The pathological pathway from high SUA to arterial stiffness was mainly mediated through hypertension (mediated proportion: 24.74%). Our study indicate that SUA was positively associated with the risk of arterial stiffness and its progression, especially in women. The association was mainly mediated through hypertension.