Key result
Diastolic dysfunction, indicated by E/E' > 15, significantly increased the risk of cardiovascular events by over 5-fold (HR 5.40) in incident dialysis patients with preserved systolic function.
Cohort (n=194)
No
Effect estimate: HR 5.40 (95% CI 2.73-10.70)
p-value: p=<0.001
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May refine CV risk prediction in incident dialysis; hypothesis-generating and needs prospective validation before practice change.
Han et al. (2015) conducted a cohort in Incident end-stage renal disease (ESRD) on dialysis with preserved systolic function (n=194). Diastolic dysfunction (E/E' > 15) vs. Normal diastolic function (E/E' ≤ 15) was evaluated on Cardiovascular events (HR 5.40, 95% CI 2.73-10.70, p=<0.001). Diastolic dysfunction, indicated by E/E' > 15, significantly increased the risk of cardiovascular events by over 5-fold (HR 5.40) in incident dialysis patients with preserved systolic function.
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