What question did this study set out to answer?

To determine whether pulse wave characteristics and the maximal rate of pressure rise (dp/dt max) govern the propagation and rupture of acute dissecting aneurysms.

July 1, 1970Circulation ResearchOpen Access

Hydrodynamic Forces in Dissecting Aneurysms

View Full Paper

Ask AI

Bookmark

Authors

EPEdward K. ProkopHartford Hospital RPRoger F. PalmerUniversity of Miami MWMyron W. WheatSprint (United States)

Discussion

Member takes

Implication

Experimental study reveals that pulsatile flow and maximum pressure rates drive aortic dissection in synthetic and canine vessels, indicating pulse wave dynamics govern tear propagation.

Key Points

To determine whether pulse wave characteristics and the maximal rate of pressure rise (dp/dt max) govern the propagation and rupture of acute dissecting aneurysms.
Constructed a standard synthetic aorta model using an outer Tygon tube and an inner rubber cement lining with an induced intimal tear.
Subjected synthetic and excised canine aortic models to incremental nonpulsatile and pulsatile fluid flows across various pressures and dp/dt max values (including 97 nonpulsatile experiments).
Nonpulsatile flow failed to cause dissection across 97 experiments, even at hydrostatic pressures reaching 400 mm Hg.
Pulsatile flow produced rapid dissection at a maximum systolic pressure of 120 mm Hg once dp/dt max exceeded a critical threshold of 790 mm Hg/sec in synthetic tubes and 3800 mm Hg/sec in canine aortas.
Canine aortas undergoing pulsatile dissection either ruptured externally through the outer wall or reentered the vessel lumen.

Cite This Study

Prokop et al. (1970) studied this question.

synapsesocial.com/papers/6a14f5802f0e848eb39aeebf https://doi.org/10.1161/01.res.27.1.121

View Full Paper

Ask AI

Bookmark

Implication

Experimental study reveals that pulsatile flow and maximum pressure rates drive aortic dissection in synthetic and canine vessels, indicating pulse wave dynamics govern tear propagation.

Hydrodynamic Forces in Dissecting Aneurysms

Discussion

Member takes

Implication

Key Points

Cite This Study

Hydrodynamic Forces in Dissecting Aneurysms

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider