Key result
Angelis' salt (HNO/NO-) increased load-independent contractility by 47% and enhanced relaxation in failing canine hearts, independent of and additive to beta-adrenergic stimulation.
Why the study?
Does HNO/NO(-) improve systolic and diastolic function in dogs with pacing-induced heart failure?
Population
Conscious dogs with cardiac failure induced by chronic tachycardia pacing
Comparison
HNO/NO generated by Angelis' salt infused vs NO donor diethylamineNO or nitroglycerin, and…
Design
Preclinical
Authors
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Should not yet change HF practice; extends HNO/NO- benefits to failing hearts, hypothesis-generating for translation.
Does HNO/NO(-) improve systolic and diastolic function in dogs with pacing-induced heart failure?
Absolute Event Rate: 13.8% vs 9.51%
p-value: p=<0.001
HNO/NO(-) donors improve contractility and relaxation in failing hearts independently of beta-adrenergic signaling, highlighting their potential as a novel heart failure therapy.
Paolocci et al. (2003) studied Congestive heart failure (n=20). Angelis' salt (HNO/NO- donor) vs. Baseline and NO donors (DEA/NO, NTG) was evaluated on End-systolic elastance (Ees) in mmHg/ml (p=<0.001). Angelis' salt (HNO/NO-) increased load-independent contractility by 47% and enhanced relaxation in failing canine hearts, independent of and additive to beta-adrenergic stimulation.
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