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June 1, 1995Journal of Biological ChemistryOpen Access

Nitric Oxide-dependent Parasympathetic Signaling Is Due to Activation of Constitutive Endothelial (Type III) Nitric Oxide Synthase in Cardiac Myocytes

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Key result

Nitric oxide-dependent parasympathetic signaling in cardiac myocytes is mediated by the constitutive endothelial isoform of nitric oxide synthase (NOS III).

Population

Cardiac myocytes

Design

Preclinical

Authors

JBJean‐Luc BalligandHeart Failure & TransplantLKLester KobzikIo Therapeutics (United States)XHXinqiang HanUniversity of Minnesota Medical Center

Discussion

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Overview

Animal findings on NOS III require human validation; extends mechanistic insight but leaves open clinical relevance.

Structured PICO

P
Population
Cardiac myocytes
I
Intervention
NOS inhibitors
O
Outcome
Expression and localization of NOS III, and effects on single myocyte L-type calcium current and contractilitysurrogate

This preclinical study demonstrates that cardiac myocytes constitutively express endothelial NOS (NOS III), which mediates NO-dependent parasympathetic signaling.

Cite This Study

Balligand et al. (1995) studied this question. NOS inhibitors was evaluated on NOS III expression and functional role in NO-dependent parasympathetic signaling. Nitric oxide-dependent parasympathetic signaling in cardiac myocytes is mediated by the constitutive endothelial isoform of nitric oxide synthase (NOS III).

synapsesocial.com/papers/6a14f5fa9ff8b2b0e129e032https://doi.org/10.1074/jbc.270.24.14582
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.1992 · 993 citations
  2. 2Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs.1995 · 175 citations
  3. 3Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.1993 · 780 citations
  4. 4Regulation of Cardiac L-Type Calcium Current by Phosphorylation and G Proteins1990 · 361 citations
  5. 5Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.1993 · 455 citations