Key result
Transfecting NOS3-null mice with myocyte-specific NOS3 restored a positive heart rate response (P<0.001) and normalized beta-adrenergic and muscarinic cardiac regulation.
Why the study?
Does myocyte-specific NOS3 expression modulate in vivo cardiac function in NOS3-null mice?
Does myocyte-specific NOS3 expression modulate in vivo cardiac function in NOS3-null mice?
p-value: p=<0.001
Myocyte autocrine/intracrine NOS3 regulation in vivo plays key roles in beta-adrenergic, muscarinic, and frequency-dependent cardiac regulation.
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Myocyte NOS3 may modulate cardiac autonomic responses in mice; hypothesis-generating and leaves open translation to human disease.
Champion et al. (2004) studied NOS3-null mice. Adenovirus-expressing NOS3 coupled to a alpha-MHC promoter (AdV(NOS3)) vs. Marker-gene beta-galactosidase (AdVbeta(gal)) and wild-type (WT) was evaluated on Cardiac function (ejection function, isoproterenol-stimulated systolic/diastolic function, rate response) (p=<0.001). Transfecting NOS3-null mice with myocyte-specific NOS3 restored a positive heart rate response (P<0.001) and normalized beta-adrenergic and muscarinic cardiac regulation.
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