Why the study?
Does cardiomyocyte-restricted overexpression of NOS3 alter cardiac contraction and autonomic responsiveness in murine models?
Does cardiomyocyte-restricted overexpression of NOS3 alter cardiac contraction and autonomic responsiveness in murine models?
Moderate overexpression of NOS3 targeted to caveolae in murine cardiomyocytes attenuates beta-adrenergic stimulation and reinforces vagal inhibition, suggesting a potential therapeutic target to restore sympathovagal balance.
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NOS3 modulation of autonomic responses remains preclinical; leaves open therapeutic translation for human sympathovagal imbalance.
Massion et al. (2004) studied this question.
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