Key result
Concurrent intracoronary acetylcholine reduced the dobutamine-stimulated increase in left ventricular +dP/dt by 66±10% in normal subjects and 79±9% in transplant recipients.
Why the study?
Do intracoronary acetylcholine and atropine modulate basal and dobutamine-stimulated left ventricular contractility in normal subjects and cardiac transplant recipients?
Do intracoronary acetylcholine and atropine modulate basal and dobutamine-stimulated left ventricular contractility in normal subjects and cardiac transplant recipients?
Stimulation and inhibition of cholinergic receptors in the human heart can modulate the positive inotropic response to beta-adrenergic stimulation.
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Attenuates beta-adrenergic inotropy via cholinergic stimulation in human myocardium; leaves open clinical relevance in transplant or HF patients.
Landzberg et al. (1994) studied Normal left ventricular function and cardiac transplantation (n=13). Intracoronary acetylcholine and atropine vs. Dobutamine alone and basal state was evaluated on Changes in left ventricular contractile function assessed by measurement of peak +dP/dt. Concurrent intracoronary acetylcholine reduced the dobutamine-stimulated increase in left ventricular +dP/dt by 66±10% in normal subjects and 79±9% in transplant recipients.
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