Key result
The fibrillin-1 2-3 genotype was associated with higher input impedance (P=0.002), characteristic impedance (P=0.005), and carotid pulse pressure (P=0.002) compared with 2-2 and 2-4 genotypes.
Why the study?
Is the fibrillin-1 genotype associated with aortic stiffness and disease severity in patients with coronary artery disease?
Observational (n=145)
Is the fibrillin-1 genotype associated with aortic stiffness and disease severity in patients with coronary artery disease?
p-value: p=0.002
Fibrillin-1 genotype is associated with large-artery stiffening and pulse pressure elevation in individuals with coronary disease, suggesting a genetic basis for this cardiovascular risk factor.
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Should not yet inform CAD management; leaves open whether fibrillin-1 variants predict progression or outcomes.
Medley et al. (2002) conducted an observational in Coronary Artery Disease (n=145). Fibrillin-1 genotype (2-3 genotype) vs. Fibrillin-1 2-2 and 2-4 genotypes was evaluated on Input impedance, characteristic impedance, and carotid pulse pressure (p=0.002). The fibrillin-1 2-3 genotype was associated with higher input impedance (P=0.002), characteristic impedance (P=0.005), and carotid pulse pressure (P=0.002) compared with 2-2 and 2-4 genotypes.
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