Key result
Isoproterenol and rapid pacing steepened action potential duration restitution and increased AF incidence (from 12% at baseline to 64% and 84%, respectively; P<0.05) via reduced activation latency.
Why the study?
Does isoproterenol, adenosine, or rapid pacing alter action potential duration restitution and activation latency to initiate atrial fibrillation in patients?
Population
50 patients (20 with persistent atrial fibrillation, 23 with paroxysmal atrial fibrillation, 7 controls)
Comparison
Isoproterenol, adenosine, or rapid pacing during… vs Baseline measurements prior to intervention and…
Design
Cohort
Authors
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Supports steep APD restitution as AF trigger pathway for isoproterenol or pacing; hypothesis-generating for latency-targeted interventions.
Does isoproterenol, adenosine, or rapid pacing alter action potential duration restitution and activation latency to initiate atrial fibrillation in patients?
p-value: p=<0.05
Steep action potential duration restitution, facilitated by reduced activation latency, is a common mechanistic pathway for atrial fibrillation initiation by isoproterenol and rapid pacing.
Krummen et al. (2012) studied Atrial fibrillation (n=50). Isoproterenol, adenosine, or rapid pacing vs. Baseline and controls was evaluated on Left atrial action potential duration (APD) restitution, activation latency, and AF incidence (p=<0.05). Isoproterenol and rapid pacing steepened action potential duration restitution and increased AF incidence (from 12% at baseline to 64% and 84%, respectively; P<0.05) via reduced activation latency.
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