Reinduction of Atrial Fibrillation Immediately After Termination of the Arrhythmia Is Mediated by Late Phase 3 Early Afterdepolarization–Induced Triggered Activity
Key result
In isolated canine atria, calcium overload after termination of vagally mediated AF contributes to late phase 3 early afterdepolarization-induced triggered activity, which can reinitiate AF.
Population
Isolated coronary-perfused canine right atria (n=9)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No immediate clinical implications; leaves open whether calcium handling modulates AF recurrence in patients.
Structured PICO
P
Population
Isolated coronary-perfused canine right atria (n=9)
I
Intervention
Acetylcholine (1 micromol/L) with rapid pacing, followed by nifedipine or ryanodine
O
Outcome
Mechanism of AF reinduction (transmembrane action potentials, pseudo-ECG, and tension development)surrogate
Calcium overload after termination of vagally mediated AF contributes to late phase 3 EAD-induced triggered activity, which may reinitiate AF.
Cite This Study
Burashnikov et al. (2003) studied Atrial fibrillation (n=9). Acetylcholine and rapid pacing was evaluated on Development of late phase 3 early afterdepolarizations (EADs), extrasystoles, and reinitiation of AF. In isolated canine atria, calcium overload after termination of vagally mediated AF contributes to late phase 3 early afterdepolarization-induced triggered activity, which can reinitiate AF.