Key result
In patients with atrial fibrillation, the degree of left atrial fibrosis was significantly associated with depressed left ventricular ejection fraction, decreasing from 60.5% in minimal fibrosis to 48.9% in extensive fibrosis.
Why the study?
Does the degree of left atrial fibrosis correlate with left ventricular ejection fraction in patients with atrial fibrillation?
Observational (n=384)
No
Does the degree of left atrial fibrosis correlate with left ventricular ejection fraction in patients with atrial fibrillation?
Effect estimate: OR 0.53 (95% CI 0.41-0.69)
Absolute Event Rate: 48.9% vs 60.5%
p-value: p=<0.001
Extensive left atrial fibrosis is independently associated with depressed left ventricular ejection fraction in patients with atrial fibrillation, suggesting a link between atrial and ventricular structural remodeling.
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Association supports linked remodeling hypothesis in AF; leaves open whether fibrosis assessment improves risk stratification.
Mehmet Akkaya (2014) conducted an observational in Atrial fibrillation (n=384). Extensive left atrial fibrosis (Utah stage 4) vs. Minimal left atrial fibrosis (Utah stage 1, <5% fibrosis) was evaluated on Pre-ablation left ventricular ejection fraction (LVEF) (OR 0.53, 95% CI 0.41-0.69, p=<0.001). In patients with atrial fibrillation, the degree of left atrial fibrosis was significantly associated with depressed left ventricular ejection fraction, decreasing from 60.5% in minimal fibrosis to 48.9% in extensive fibrosis.
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