Why the study?
Conventional LGE sequences lack sufficient spatial resolution to accurately depict the thin atrial wall, and reference data in healthy cohorts are scarce.
Does high-resolution isotropic 3D LGE imaging accurately quantify left atrial fibrosis and post-ablation scarring compared to electroanatomical mapping in AF patients?
Population
40 ablation-naïve AF patients and 20 healthy controls
Comparison
Isotropic 3D LGE imaging across AF subtypes, healthy controls, and post-ablation
Design
Prospective study
Follow-up
Six months post ablation
Key result
High-resolution isotropic 3D LA-LGE imaging detected higher total left atrial enhancement in persistent AF (3.65%) compared to paroxysmal AF (1.16%, P=0.044) and healthy controls (1.25%, P=0.041).
Authors
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High-resolution 3D LGE Dixon enables LA fibrosis reference values in healthy subjects; leaves open its prognostic utility in AF cohorts.
Observational (n=60)
Does high-resolution isotropic 3D LGE imaging accurately quantify left atrial fibrosis and post-ablation scarring compared to electroanatomical mapping in AF patients?
Absolute Event Rate: 3.65% vs 1.16%
p-value: p=0.044
High-resolution 3D LA-LGE can detect ablation-induced scarring and differences between AF stages, but correlates poorly with bipolar voltage mapping, suggesting they provide complementary information.
Fenski et al. (2026) conducted an observational in Atrial fibrillation (n=60). High-resolution isotropic 3D LGE imaging vs. Paroxysmal AF and healthy controls was evaluated on Total LA enhancement at baseline (p=0.044). High-resolution isotropic 3D LA-LGE imaging detected higher total left atrial enhancement in persistent AF (3.65%) compared to paroxysmal AF (1.16%, P=0.044) and healthy controls (1.25%, P=0.041).
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