Key result
Novel tool isolates atrial signals from ventricular mixing to analyze AF substrate irregularity in rodents.
Why the study?
Most rodent AF studies do not discriminate between irregular and regular atrial arrhythmias due to technical difficulties such as atrial waveform mixing by ventricular signals.
A novel computerized tool was developed to isolate atrial signals from ventricular mixing in rodents, facilitating standardized and objective atrial fibrillation research.
May standardize rodent AF analysis; leaves open human translation pending validation.
Rodents are increasingly used in AF research. However, because of technical difficulties including atrial waveform mixing by ventricular signals, most studies do not discriminate between irregular (i.e., AF) and regular atrial arrhythmias. Here, we develop an unbiased computerized tool to "pure" the atrial signals from ventricular mixing and thereafter analyze AF substrate based on the level of irregularity in an objective manner. This novel tool can facilitate standardized AF research in rodents.
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Murninkas et al. (2023) studied Atrial fibrillation. Computerized tool for quantifying AF substrate was evaluated on Level of irregularity in atrial signals. A novel computerized tool was developed to separate atrial signals from ventricular mixing and objectively analyze atrial fibrillation substrate irregularity in rodents.
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