Why the study?
Technical challenges restrict long-term supraventricular electrophysiology studies in rodents, despite their increasing use in AF research.
A newly developed implantable electrode enables long-term assessment of supraventricular electrophysiology and AF susceptibility in freely moving rats.
Enables chronic rat AF electrophysiology; leaves open translation to human mechanisms pending validation.
Rodents are increasingly used in AF research. However, technical challenges restrict long-term supraventricular electrophysiology studies in these species. Here, we developed an implantable electrode adapted for such studies in the rat. Our findings indicate that this new tool is effective for long-term follow-up of critical parameters such as atrial refractoriness. Obtained data shed light on the normal electrophysiology and on the increased AF susceptibility that develops in rats with implanted atrial electrodes over time.
No takes yet. Share an insight, caveat, or question.
Murninkas et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: