Key result
Transvenous catheter-based AF duration was significantly longer in middle-aged than in young rats and was markedly reduced by treatment with pilsicainide or amiodarone.
Why the study?
Does transvenous catheter-based atrial burst pacing reliably induce atrial fibrillation in rats, and how do age and antiarrhythmic drugs affect its duration?
Does transvenous catheter-based atrial burst pacing reliably induce atrial fibrillation in rats, and how do age and antiarrhythmic drugs affect its duration?
A transvenous catheter-based rat model of AF is reproducible and demonstrates that AF duration increases with age and is reduced by antiarrhythmic drugs, providing a reliable model for studying atrial remodeling and pharmacology.
Establishes reproducible rat AF model for age and drug studies; leaves open human translation.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2009) studied Atrial fibrillation (n=38). Pilsicainide or amiodarone vs. Untreated middle-aged rats was evaluated on AF inducibility and duration. Transvenous catheter-based AF duration was significantly longer in middle-aged than in young rats and was markedly reduced by treatment with pilsicainide or amiodarone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: