Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat.
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Discussion
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Implication
Randomized trial examines cardiac output changes in hypertrophied left ventricles of different age groups of spontaneously hypertensive rats, highlighting potential deterioration with age.
Key Points
- The research aims to assess how cardiac pumping ability is affected during the development of left ventricular hypertrophy in spontaneously hypertensive rats.
- Infused Tyrode's solution intravenously to elevate venous pressure and measure peak cardiac output.
- Experiments conducted on spontaneously hypertensive rats across three age groups: 11, 24, and 83 weeks.
- Comparison made between the hypertensive rats and two strains of normotensive rats.
- From 11 to 24 weeks, peak cardiac output increased in SHR proportionally to ventricular mass, with stable output per gram of LV.
- Age-matched normotensive rats showed stable peak cardiac output per gram of LV across ages with varying weights.
- In 83-week SHR, severe hypertrophy led to a 100% increase in left ventricular to body weight ratio and a marked reduction in pumping ability per gram of LV.
Cite This Study
Pfeffer et al. (1976) studied this question.