March 1, 1990Cardiovascular Research

Left ventricular hypertrophy in WKY-CH rats allowed a higher peak cardiac index (427) compared to normotensive WKY rats (315) and SHR (349) (p<0.05).

Q: What is the clinical evidence from this study?

Study design: Other. Population: Left ventricular hypertrophy (n=25). Intervention: Left ventricular hypertrophy (WKY-CH and SHR models) vs. Normotensive Wistar Kyoto (WKY) rats. Primary outcome: Peak cardiac index (ml.min-1.body weight-1) (p=<0.05).

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Key result

Left ventricular hypertrophy in WKY-CH rats allowed a higher peak cardiac index (427) compared to normotensive WKY rats (315) and SHR (349) (p<0.05).

Authors

RTRobert J. Tomanek MWMadelyn Whitaker

Discussion

Member takes

Overview

LVH may enhance peak cardiac index in this rat model; leaves open relevance to human hypertension.

PICO

Population

25 rats (WKY, WKY-CH, and SHR) at one year of age studied to compare peak left ventricular performance in models of normal and increased peripheral resistance.

Exposure / Comparator

Left ventricular hypertrophy (WKY-CH and SHR models) vs Normotensive Wistar Kyoto (WKY) rats

Primary Outcome

Peak cardiac index (ml.min-1.body weight-1), p=<0.05

Main Result

Absolute Event Rate: 427% vs 315%

p-value: p=<0.05

Cite This Study

Tomanek et al. (1990) studied Left ventricular hypertrophy (n=25). Left ventricular hypertrophy (WKY-CH and SHR models) vs. Normotensive Wistar Kyoto (WKY) rats was evaluated on Peak cardiac index (ml.min-1.body weight-1) (p=<0.05). Left ventricular hypertrophy in WKY-CH rats allowed a higher peak cardiac index (427) compared to normotensive WKY rats (315) and SHR (349) (p<0.05).

synapsesocial.com/papers/6a93c4b3a05f7032207c06bc https://doi.org/10.1093/cvr/24.3.204

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March 1, 1990Cardiovascular Research

Left ventricular hypertrophy in WKY-CH rats allowed a higher peak cardiac index (427) compared to normotensive WKY rats (315) and SHR (349) (p<0.05).

View Full Paper

Ask AI

Bookmark

Key result

Left ventricular hypertrophy in WKY-CH rats allowed a higher peak cardiac index (427) compared to normotensive WKY rats (315) and SHR (349) (p<0.05).

Authors

RTRobert J. Tomanek MWMadelyn Whitaker

Discussion

Member takes

Overview

LVH may enhance peak cardiac index in this rat model; leaves open relevance to human hypertension.

PICO

Population

25 rats (WKY, WKY-CH, and SHR) at one year of age studied to compare peak left ventricular performance in models of normal and increased peripheral resistance.

Exposure / Comparator

Left ventricular hypertrophy (WKY-CH and SHR models) vs Normotensive Wistar Kyoto (WKY) rats

Primary Outcome

Peak cardiac index (ml.min-1.body weight-1), p=<0.05

Main Result

Absolute Event Rate: 427% vs 315%

p-value: p=<0.05

Cite This Study

synapsesocial.com/papers/6a93c4b3a05f7032207c06bc https://doi.org/10.1093/cvr/24.3.204

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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