Population
Isolated left ventricular papillary muscle from male spontaneously hypertensive rats and age-matched…
Comparison
Volume overload induced by aortocaval fistula… vs Control rats without aortocaval fistula
Design
Preclinical
Follow-up
30 days
Key result
A 30-day period of volume overload via aortocaval fistula caused more mechanical functional changes, including increased relaxation time, in hypertrophied rat myocardium than in normal myocardium.
Authors
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May warrant cautious volume management in hypertrophied hearts; leaves open translation to human HF.
p-value: p=<0.05
In a rat model, hypertrophied myocardium demonstrated greater sensitivity to mechanical functional changes from volume overload compared to normal myocardium.
Cicogna et al. (2002) studied Cardiac hypertrophy and volume overload (n=38). Aortocaval fistula (ACF) vs. No ACF (Control) was evaluated on Mechanical function of isolated left ventricular papillary muscle (Developed tension and relaxation time) (p=<0.05). A 30-day period of volume overload via aortocaval fistula caused more mechanical functional changes, including increased relaxation time, in hypertrophied rat myocardium than in normal myocardium.
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