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March 8, 2006European Journal of Heart FailureOpen Access

Infrarenal arteriovenous fistula in rats significantly decreased +dP/dt (2769 vs 3318 mm Hg s-1, P=0.002) and increased ventricular compliance compared to SHAM operation.

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Why the study?

Does volume overload induced by arteriovenous fistula cause myocardial systolic and diastolic dysfunction in rats?

Population

24 male Wistar rats

Comparison

Volume overload myocardial hypertrophy induced… vs SHAM operated group

Design

Preclinical

Follow-up

8 weeks

Key result

Infrarenal arteriovenous fistula in rats significantly decreased +dP/dt (2769 vs 3318 mm Hg s-1, P=0.002) and increased ventricular compliance compared to SHAM operation.

Authors

LSLaercio Martins De StefanoLMLuiz Shiguero MatsubaraBMBeatriz B. Matsubara

Discussion

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Overview

Animal findings on overload hypertrophy should not alter clinical HF management; leaves open human translation of systolic-diastolic dissociation.

Key Points

  • The study aims to evaluate the effects of volume overload on myocardial systolic and diastolic function in an animal model.
  • Male Wistar rats (N=13) underwent arteriovenous fistula (AVF) creation to induce hypertrophy; a SHAM group (n=11) served as controls.
  • Tail-cuff blood pressure was measured, followed by isolated heart studies using Langendorff's preparation.
  • Comparisons were made on ventricular weights, compliance, and hemodynamic parameters post-surgery.
  • AVF rats showed increased left and right ventricular weights compared to controls (P<0.001).
  • Significant decrease in +dP/dt (3318 vs. 2769 mm Hg s(-1); P=0.002) and end-systolic pressure-volume relation (246 vs. 114 mm Hg mL(-1); P<0.001) in AVF group.
  • Increased ventricular compliance in AVF rats (DeltaV(25): SHAM=0.172 vs. AVF=0.321 mL; P<0.001), with preserved passive stiffness.

Structured PICO

Does volume overload induced by arteriovenous fistula cause myocardial systolic and diastolic dysfunction in rats?

P
Population
24 male Wistar rats subjected to infrarenal arteriovenous fistula to induce volume overload myocardial hypertrophy or SHAM operation, evaluated at 8 weeks.
I
Intervention
Volume overload myocardial hypertrophy induced by creating infrarenal arteriovenous fistula (AVF)
C
Comparator
SHAM operated group
O
Outcome
Systolic and diastolic function evaluated via isolated heart studies using Langendorff's preparationsurrogate

Main Result

Absolute Event Rate: 2769% vs 3318%

p-value: p=0.002

Volume-overload induced hypertrophy causes myocardial systolic and diastolic dysfunction with increased ventricular compliance, which may explain the long-term compensatory phase before overt heart failure.

Cite This Study

Stefano et al. (2006) studied Volume overload induced myocardial hypertrophy (n=24). Infrarenal arteriovenous fistula (AVF) vs. SHAM operated group was evaluated on +dP/dt (p=0.002). Infrarenal arteriovenous fistula in rats significantly decreased +dP/dt (2769 vs 3318 mm Hg s-1, P=0.002) and increased ventricular compliance compared to SHAM operation.

synapsesocial.com/papers/6a6ae2b001245da06ecb53d4https://doi.org/10.1016/j.ejheart.2006.02.005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Volume Overload Influence on Hypertrophied Myocardium Function.2002 · 9 citations
  2. 2Temporal evaluation of left ventricular remodeling and function in rats with chronic volume overload1996 · 115 citations
  3. 3Improved Systolic Ventricular Function With Normal Myocardial Mechanics in Compensated Cardiac Hypertrophy2004 · 45 citations
  4. 4Mechanical regulation of myocardial growth during volume-overload hypertrophy in the rat1997 · 45 citations
  5. 5Myocardial blood flow and mechanics in volume overload-induced left ventricular hypertrophy in dogs1981 · 21 citations