Population
Rats with an arteriovenous fistula (AVF) model of volume-overload hypertrophy
Comparison
Arteriovenous fistula (AVF) creation vs Baseline/control rats
Design
Preclinical
Follow-up
6 weeks
Key result
Arteriovenous fistula-induced volume overload acutely increased end-diastolic strain from 0.056 to 0.110 (P<0.05), which normalized by 6 weeks despite persistently elevated fiber stress.
Authors
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No immediate clinical implications; extends mechanistic insights on strain adaptation in experimental volume overload.
Absolute Event Rate: 0.11% vs 0.056%
p-value: p=< 0.05
In a rat model of volume-overload hypertrophy, end-diastolic strain, rather than stress, normalizes over 6 weeks through changes in ventricular geometry and wall stiffness.
Emery et al. (1997) studied Volume-overload hypertrophy. Arteriovenous fistula (AVF) vs. Baseline/control was evaluated on Mean strain in the muscle fiber direction (Eff) at end-diastolic pressure (p=< 0.05). Arteriovenous fistula-induced volume overload acutely increased end-diastolic strain from 0.056 to 0.110 (P<0.05), which normalized by 6 weeks despite persistently elevated fiber stress.
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