Population
Male Sprague-Dawley rats
Comparison
Surgical creation of an infrarenal arteriovenous… vs Sham operation
Design
Preclinical
Follow-up
4 and 7 days
Key result
Surgical creation of an infrarenal arteriovenous fistula in rats produced a 66% increase in cardiac output and a 10% increase in left ventricular mass by day 7.
Authors
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Time-varying LV volume features may drive early overload hypertrophy; leaves open mechanistic targets for human studies.
Features of the time-varying ventricular volume signal, rather than peak systolic wall stress or diastolic strain, may drive hypertrophy during early volume overload.
Jeffrey W. Holmes (2004) studied Volume overload. Surgical creation of an infrarenal arteriovenous fistula vs. Sham operation was evaluated on Left ventricular volume and wall stress signals. Surgical creation of an infrarenal arteriovenous fistula in rats produced a 66% increase in cardiac output and a 10% increase in left ventricular mass by day 7.
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