Why the study?
Does pressure overload hypertrophy induced by transverse aortic constriction alter myocardial stress-strain relations and systolic/diastolic function in mice?
Population
Normal mice and mice with pressure overload hypertrophy induced by 7 days of transverse aortic constriction
Comparison
Transverse aortic constriction (TAC) for 7 days vs Normal control mice
Design
Preclinical
Follow-up
7 days
Authors
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Increased systolic stiffness in murine TAC supports early compensatory hypertrophy; hypothesis-generating for human pressure-overload translation.
Does pressure overload hypertrophy induced by transverse aortic constriction alter myocardial stress-strain relations and systolic/diastolic function in mice?
In a murine model, early pressure overload cardiac hypertrophy is associated with a heightened contractile state but abnormal diastolic properties, suggesting an early compensatory response.
Takaoka et al. (2002) studied this question.
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