January 1, 2002Circulation
Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress
Why the study?
Does genetic inhibition of cardiac hypertrophy prevent cardiac dysfunction despite increased wall stress in pressure-overloaded mice?
Population
2 genetically altered mouse models with an attenuated hypertrophic response to pressure overload, and…
Comparison
8 weeks of pressure overload in genetically… vs Wild-type mice with similar pressure overload…
Design
Preclinical
Follow-up
8 weeks
Authors
Discussion
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Member takes
Implication
Challenges compensatory hypertrophy paradigm in pressure overload; leaves open translation to human cardiac dysfunction.
Structured PICO
Does genetic inhibition of cardiac hypertrophy prevent cardiac dysfunction despite increased wall stress in pressure-overloaded mice?
P
Population
2 genetically altered mouse models with an attenuated hypertrophic response to pressure overload, and wild-type mice
I
Intervention
8 weeks of pressure overload in genetically altered mice with blunted hypertrophic response
C
Comparator
Wild-type mice with similar pressure overload and sham-operated mice
O
Outcome
Cardiac function (measured by serial echocardiography) and end-systolic wall stresssurrogate
Genetic inhibition of pressure-overload hypertrophy prevents cardiac dysfunction despite increased wall stress, challenging the hypothesis that hypertrophy is a necessary compensatory mechanism.
Cite This Study
Esposito et al. (2002) studied this question.