Key result
Inhibiting cardiac hypertrophy per se may not improve outcomes in ventricular pressure overload.
Why the study?
The concept that preventing hypertrophy during ventricular pressure overload is beneficial has been widely accepted, but a comprehensive evaluation of experimental results is necessary.
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Questions hypertrophy inhibition as a target in pressure overload; leaves optimal therapeutic strategies open for clinical investigation.
Crozatier et al. (2015) conducted a review in Ventricular pressure overload and cardiac hypertrophy. Inhibition of hypertrophy was evaluated. Inhibition of cardiac hypertrophy per se may not be an optimal therapeutic strategy for ventricular pressure overload, suggesting other approaches could be more beneficial.
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