Short-term pressure-overload right ventricular hypertrophy-failure increases passive myocardial stiffness in cats, which may contribute to decreased systolic performance.
Answers are grounded in this paper and cite their sources.
Should not change HF management; leaves open stiffness contribution to systolic impairment in pressure-overload models.
The passive stress-strain relationship of right ventricular papillary muscles from 10 normal and 9 experimental cats with short-term pressure-overload right ventricular hypertrophy-failure was examined by plotting the logarithm of instantaneous stress (ln sigma) against the natural strain calculated as ln(l/l0) where l = instantaneous length and l0 = length at zero force. Such a stress-strain relationship was well approximated by a linear relationship. The slope K obtained from this linear relationship was higher in the hypertrophy-failure muscles (normal, 15.01 +/- 0.87 (SEM); hypertrophy-failure, 31.79 +/- 4.09; P less than 0.005). The value of the intercept, ln C was similar in the two groups (normal, -4.33 +/- 0.20; hypertrophy-failure, -4.71 +/- 0.10). This analysis indicates the the ln sigma-natural strain relationship is linear in the papillary muscle and the slope of this relationship, an index of stiffness, is increased in hypertrophy-failure muscles. Using a three-element muscle model, it is shown that increased diastolic stiffness may contribute to the decreased systolic performance.
No takes yet. Share an insight, caveat, or question.
Natarajan et al. (1979) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: