Key result
Pressure overload hypertrophy, but not volume overload, increases reperfusion-induced VF in rats.
Why the study?
The effect of myocardial hypertrophy type on the incidence and severity of reperfusion arrhythmias after coronary artery occlusion was unclear.
Does the type of myocardial hypertrophy (pressure vs. volume overload) affect the incidence and severity of reperfusion-induced arrhythmias in rats?
Does the type of myocardial hypertrophy (pressure vs. volume overload) affect the incidence and severity of reperfusion-induced arrhythmias in rats?
The susceptibility to reperfusion arrhythmias in hypertrophied hearts depends on the nature of the hypertrophic stimulus (pressure vs. volume overload) rather than the increase in cardiac mass alone.
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Pressure-overload hypertrophy raised reperfusion VF incidence in rats unlike volume overload; leaves open whether stimulus-specific effects inform human LVH management.
Robertson et al. (1993) studied Myocardial hypertrophy and reperfusion arrhythmias. Pressure overload hypertrophy or volume overload hypertrophy vs. Control animals was evaluated on Incidence and severity of arrhythmias following reperfusion. Pressure overload hypertrophy, but not volume overload hypertrophy, significantly increased the incidence of reperfusion-induced ventricular fibrillation in rats.
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