Key result
Pressure overload-induced left ventricular hypertrophy significantly increased the incidence of ventricular fibrillation during left coronary bed ischemia and reperfusion compared to sham operation.
Absolute Event Rate: 75% vs 25%
p-value: p=<0.05
Pressure overload-induced LV hypertrophy intrinsically increases susceptibility to ischemia- and reperfusion-induced ventricular fibrillation.
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May increase ischemia-reperfusion VF risk in hypertrophied hearts; leaves open translation to human arrhythmia prevention.
Shimada et al. (2003) studied Left ventricular hypertrophy (n=117). Abdominal aortic constriction (AC) vs. Sham operation (SH) was evaluated on Incidence of ventricular fibrillation (VF) during left coronary bed reperfusion (p=<0.05). Pressure overload-induced left ventricular hypertrophy significantly increased the incidence of ventricular fibrillation during left coronary bed ischemia and reperfusion compared to sham operation.
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