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March 12, 2004AJP Heart and Circulatory Physiology

Myocardial hypertrophy of normotensive Wistar-Kyoto rats

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Authors

EAErnesto A. AielloMVMaría C. Villa‐AbrilleEEEduardo M. Escudero

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Overview

Highlights potential non-hemodynamic drivers of hypertrophy; leaves open genetic mechanisms and human translation.

Key Points

  • To assess cellular dimensions, tissue stiffness, and fibrosis in normotensive Wistar-Kyoto rats displaying left ventricular hypertrophy compared to spontaneously hypertensive and control Wistar rats.
  • Evaluated left ventricular mass-to-body weight (LVM/BW) ratios in spontaneously hypertensive (SHR, n = 47), Wistar-Kyoto (WKY, n = 41), and Wistar rats (n = 28).
  • Measured myocyte morphology and cell capacitance, left ventricular collagen volume fraction, and papillary muscle stiffness across all three rat strains.
  • The LVM/BW ratio of WKY (2.41 ± 0.03 mg/g, n = 41) was intermediate between SHR (2.82 ± 0.04 mg/g, n = 47) and Wistar rats (1.98 ± 0.04 mg/g, n = 28).
  • Cell capacitance, myocyte cross-sectional area, collagen volume fraction (fibrosis), and papillary muscle stiffness were significantly higher in both WKY and SHR than in Wistar rats.
  • Blood pressure positively correlated with left ventricular mass in SHR, whereas no correlation was found in normotensive WKY or Wistar rats.

Cite This Study

Aiello et al. (2004) studied this question.

synapsesocial.com/papers/6a72393aac440176ef2a92aehttps://doi.org/10.1152/ajpheart.00779.2003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Compensated function in hypertrophied ventricles of Wistar Kyoto and spontaneously hypertensive rats1990 · 3 citations
  2. 2Spontaneously occurring hypertrophic cardiomyopathy in the rat. I. Pathologic features.1987 · 16 citations
  3. 3Correlations and Otherwise Between Blood Pressure, Cardiac Mass and Resistance Vessel Characteristics in Hypertensive, Normotensive and Hypertensive/Normotensive Hybrid Rats1983 · 51 citations
  4. 4Contractile properties of ventricular myocytes isolated from spontaneously hypertensive rat1992 · 37 citations
  5. 5A comparative morphometric study of the myocardium during the postnatal development in normotensive and spontaneously hypertensive rats2017 · 10 citations