Key result
Ventricular myocytes isolated from spontaneously hypertensive rats demonstrated significantly increased contraction and maximal velocity of shortening compared to normotensive controls.
Population
Ventricular myocytes isolated from 7 spontaneously hypertensive rats and 8 normotensive Wistar-Kyoto control…
Comparison
Spontaneous hypertension leading to cardiac… vs Normotensive Wistar-Kyoto (WKY) control rats
Design
Preclinical
Authors
Loading...
Contractile changes in SHR myocytes remain preliminary; leaves open relevance to human hypertensive heart disease.
Individual cardiac myocytes from spontaneously hypertensive rats exhibit increased contraction, suggesting early cardiac hypertrophy acts as a protective adaptation to overcome increased afterload.
Brooksby et al. (1992) studied Hypertension (n=15). Spontaneous hypertension (SHR strain) vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Contractile properties of individual cardiac myocytes (unloaded cell shortening). Ventricular myocytes isolated from spontaneously hypertensive rats demonstrated significantly increased contraction and maximal velocity of shortening compared to normotensive controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: