Why the study?
Does simulated ischemia alter electrophysiological responses differently in hypertrophied versus normal rat myocardium?
Does simulated ischemia alter electrophysiological responses differently in hypertrophied versus normal rat myocardium?
Hypertrophied myocardium from spontaneously hypertensive rats exhibits greater electrophysiological impairment and conduction slowing during simulated ischemia compared to normal myocardium, potentially related to increased collagen density.
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Hypertrophied rat myocardium shows greater ischemic vulnerability; leaves open relevance to human hypertensive hearts and arrhythmia risk.
Bélichard et al. (1991) studied this question.
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