Key result
A 22-year-old woman represents the first reported case of hypertrophic cardiomyopathy presenting with both a restrictive pattern and myocardial crypts, confirmed by MRI and transcatheter biopsy.
Case Report (n=1)
This report describes the first known case of hypertrophic cardiomyopathy presenting with both a restrictive pattern and myocardial crypts.
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Alerts clinicians to rare restrictive HCM with crypts in young patients; extends phenotypic spectrum but leaves open need for validation.
This report describes a 22-year-old woman who has clinical and physiologic features of a restrictive cardiomyopathy. Magnetic resonance imaging showed myocardial delayed enhancement and interventricular septal crypts characteristic of hypertrophic cardiomyopathy (HCM). Transcatheter biopsy confirmed the diagnosis, revealing marked myocyte hypertrophy, interstitial fibrosis, and fiber disarray, which are findings consistent with HCM. A review of the literature suggests that this is the first case of HCM reported with a restrictive pattern and myocardial crypts.
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Cannavale et al. (2010) conducted a case report in Hypertrophic Cardiomyopathy (n=1). A 22-year-old woman represents the first reported case of hypertrophic cardiomyopathy presenting with both a restrictive pattern and myocardial crypts, confirmed by MRI and transcatheter biopsy.
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