Why the study?
Does nitroglycerin improve regional myocardial contractile dysfunction induced by treadmill exercise or isoprenaline stimulation in dogs with coronary stenosis?
Population
Chronically instrumented dogs with stenosis of the circumflex branch of the left coronary artery
Comparison
Nitroglycerin 15 micrograms kg-1 15 min-1, i.v. vs Treadmill exercise versus isoprenaline infusion
Design
Preclinical
Authors
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Nitroglycerin response may vary by stress method in canine stenosis models; leaves open optimal stress testing for antianginal evaluation.
Does nitroglycerin improve regional myocardial contractile dysfunction induced by treadmill exercise or isoprenaline stimulation in dogs with coronary stenosis?
The antianginal efficacy of nitroglycerin in an animal model of coronary stenosis depends on the method of stress testing, being effective during exercise but not isoprenaline stimulation.
Schneider et al. (1988) studied this question.
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