What question did this study set out to answer?

August 1, 1988Circulation ResearchOpen Access

Effects of ouabain and isoproterenol on left ventricular diastolic function during low-flow ischemia in isolated, blood-perfused rabbit hearts.

View Full Paper

Ask AI

Bookmark

Authors

BLBeverly H. LorellHeart Failure / Cardiomyopathy SIS IsoyamaTohoku University WGW N GriceBoston University

Discussion

Member takes

Implication

Randomized trial reveals differing impacts of ouabain and isoproterenol on diastolic function in isolated rabbit hearts during low-flow ischemia, indicating potential clinical implications.

Key Points

This research investigates the differing effects of ouabain and isoproterenol on left ventricular diastolic function during induced ischemia.
Isolated, blood-perfused rabbit hearts were used, with 21 hearts divided among control, isoproterenol, and ouabain groups.
Hearts were subjected to 6 minutes of low-flow ischemia after administration of drugs to assess diastolic chamber distensibility.
Physiological heart rate (4 Hz) was maintained during experiments with careful monitoring of contractility and perfusion.
Neither isoproterenol nor ouabain demonstrated a positive inotropic effect compared to controls during ischemia.
Ouabain significantly decreased diastolic chamber distensibility during ischemia, which was not reversible during reperfusion.
No significant differences in oxygen supply/demand measures were found among groups, suggesting the observed effects are not due to greater metabolic failure.

Cite This Study

Lorell et al. (1988) studied this question.

synapsesocial.com/papers/6a1536a837103a43379f643d https://doi.org/10.1161/01.res.63.2.457

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial reveals differing impacts of ouabain and isoproterenol on diastolic function in isolated rabbit hearts during low-flow ischemia, indicating potential clinical implications.

Effects of ouabain and isoproterenol on left ventricular diastolic function during low-flow ischemia in isolated, blood-perfused rabbit hearts.

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of ouabain and isoproterenol on left ventricular diastolic function during low-flow ischemia in isolated, blood-perfused rabbit hearts.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider