Why the study?
Does isoproterenol produce greater peak inotropic effects compared to ouabain in an intact canine heart model?
Population
7 open-chest anesthetized dogs
Comparison
Isoproterenol infusion in increasing amounts… vs Ouabain infusion in increasing amounts until…
Design
Preclinical
Authors
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Supports greater inotropic effects with isoproterenol versus ouabain before toxicity in canine hearts; leaves open applicability to clinical practice.
Does isoproterenol produce greater peak inotropic effects compared to ouabain in an intact canine heart model?
Maximal doses of isoproterenol produce significantly greater increases in myocardial contractility and cardiac output compared to ouabain in the intact canine heart.
BEISER et al. (1970) studied this question.
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